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  • Title: A new low molecular weight heparan sulphate antagonizes kappa-carrageenan-induced thrombosis in rats.
    Author: Gervasi GB, Bartoli C, Carpita G.
    Journal: Pharmacol Res; 1991 Jul; 24(1):59-63. PubMed ID: 1658763.
    Abstract:
    Kappa-carrageenan (kappa-carrageenin; kappa-carragheen) was found to be thrombogenic in rats. After i.p. injection of 3 mg/kg of kappa-carrageenan the thrombosis extended to a maximum 7.5 cm from the tip of the tail. Infarction frequency as well as the extent of infarction were inhibited by oral administration of a new heparan sulphate of low molecular weight (LMW-HS) (alpha-idosane). Mesoglycan and heparin were active when administered by parenteral route, and aspirin showed no effect; mesoglycan was inactive at 50 mg/kg per os. The present data confirm the validity of this experimental model for evaluating the protective effects of antithrombotic drugs and show the activity of oral administration of a new drug endowed with fibrinolytic activity.
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