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  • Title: Extraurophyseal distribution of urotensin II immunoreactive neuronal perikarya and their processes.
    Author: Yulis CR, Lederis K.
    Journal: Proc Natl Acad Sci U S A; 1986 Sep; 83(18):7079-83. PubMed ID: 16593763.
    Abstract:
    The use of the unlabeled antibody enzyme method on serially adjacent sections permitted the demonstration of urotensin II (UII) and urotensin I (UI) immunoreactivities colocalized in most of the cells of the caudal neurosecretory system of Catostomus commersoni. The study of the upper regions of the central nervous system from the spinal cord anterior to the fifth preterminal vertebral region up to and including the brain stem revealed the presence of UII immunoreactivity in cerebrospinal fluid-contacting neurons, located ventral to the central canal along the entire length of the spinal cord and medulla. Beaded nerve fibers were observed projecting to the ventrolateral surface of the spinal cord and also forming a seemingly ascending immunoreactive-UII longitudinal bundle directed toward the brain. The presence of this "extraurophyseal" system of immunoreactive-UII cells and fibers suggests that the UII peptide may be released in upper regions of the central nervous system in response to stimuli conveyed via the cerebral spinal fluid. Thus, separate functions may be postulated for the urophyseal and the cerebral spinal fluid-contacting urotensin II systems.
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