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  • Title: Engineering a rhodopsin protein mimic.
    Author: Crist RM, Vasileiou C, Rabago-Smith M, Geiger JH, Borhan B.
    Journal: J Am Chem Soc; 2006 Apr 12; 128(14):4522-3. PubMed ID: 16594659.
    Abstract:
    Due to the difficulties in handling and manipulating membrane-bound proteins, such as rhodopsin, and the lack of crystallographic information on the cone opsins, we have opted to engineer a protein mimic of the transmembrane G-protein coupled receptor. Human cellular retinoic acid binding protein (CRABPII), a well studied and characterized protein, has been reengineered into a protein that now will bind retinal as a protonated Schiff base with high binding affinity (Kd = 2 nM) mimicking that of rhodopsin.
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