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  • Title: Pacemaker-induced mitral regurgitation as a cause of refractory congestive heart failure during pacing therapy in a patient with hypertrophic obstructive cardiomyopathy.
    Author: Kataoka H.
    Journal: Congest Heart Fail; 2006; 12(2):112-5. PubMed ID: 16596049.
    Abstract:
    This report describes a woman with hypertrophic obstructive cardiomyopathy in whom initial hemodynamic improvement by dual chamber (DDD) pacing with short atrioventricular delay was excellent, but severe mitral regurgitation developed during the subsequent follow-up period, resulting in refractory congestive heart failure. There were two possible explanations for the origin of the complicating mitral regurgitation in this patient: pacing-induced semiclosure of the mitral valve, or left ventricular asynchrony caused by right ventricular pacing. Heart failure in patients with hypertrophic obstructive cardiomyopathy who undergo placement of a DDD pacemaker to improve not only mitral regurgitation but also heart failure symptoms can be associated with systolic mitral regurgitation as the cause of failure in DDD pacing therapy.
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