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  • Title: Increased expression of membrane TNF-alpha on activated peripheral CD8+ T cells in systemic lupus erythematosus.
    Author: Horiuchi T, Morita C, Tsukamoto H, Mitoma H, Sawabe T, Harashima S, Kashiwagi Y, Okamura S.
    Journal: Int J Mol Med; 2006 May; 17(5):875-9. PubMed ID: 16596274.
    Abstract:
    Membrane TNF-alpha is a precursor form of soluble TNF-alpha and exerts pro-inflammatory functions in a cell-to-cell contact manner. We showed that membrane TNF-alpha is induced upon activation on the cell surface of CD4+ T cells and CD8+ T cells. In patients with systemic lupus erythematosus (SLE), the percentage of membrane TNF-alpha-bearing CD8+ T cells (41.5+/-12.3%) was significantly higher compared with those of healthy controls (26.7+/-3.9%) (p=0.007) or patients with rheumatoid arthritis (29.8+/-15.4%) (p=0.038). Membrane TNF-alpha-bearing CD8+ T cells from SLE patients displayed cytotoxic activity against L929 cells. It is possible that membrane TNF-alpha may be involved in the increased apoptosis and the generation of autoantigens in SLE.
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