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  • Title: Drug-eluting stent strut distribution: a comparison between Cypher and Taxus by optical coherence tomography.
    Author: Suzuki Y, Ikeno F, Yeung AC.
    Journal: J Invasive Cardiol; 2006 Mar; 18(3):111-4. PubMed ID: 16598109.
    Abstract:
    OBJECTIVES: The purpose of this study is to compare the stent strut distribution between Cypher and Taxus stents by using optical coherence tomography (OCT) in a phantom model. BACKGROUND: Previous studies demonstrated that the distribution of stent struts might affect amount of neointima proliferation after drug-eluting stent (DES) implantation. METHODS: We developed experimental models made of silicon tubing angled at 0 degrees, 30 degrees, and 60 degrees. Testing was performed on two types of stents, Cypher and Taxus, which represent current FDA-approved DES. After deployment, OCT was performed and measurements were obtained as follows at two cross sections; maximum and minimum numbers of visualized stent strut sites: (1) number of visualized stent struts; (2) angle between stent struts (interstrut angle); (3) mean interstrut angle; (4) the delta mean angle was defined as the margin between each value of the interstrut angle and mean interstrut angle. RESULTS: In the Cypher stent, both the interstrut angle and the delta mean angle were significantly better than all other stents evaluated (all comparisons between stents; p < 0.05, respectively). CONCLUSIONS: The present study found that the stent strut distribution of two stents, Cypher and Taxus, which represent current FDA-approved drug-eluting systems, were significantly different and suggested that the Cypher stent maintained a more regular strut distribution despite expansion in various anatomical situations, and therefore would provide the most regular and predictable drug delivery.
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