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  • Title: Synaptosomal respiration: a potent indicator of veratridine-induced Na influx.
    Author: Urenjak J, Tegtmeier F, Beile A, Khan S, Peters T.
    Journal: Pharmacology; 1991; 43(1):26-35. PubMed ID: 1660158.
    Abstract:
    Inhibition of the voltage-dependent Na channel by tetrodotoxin (5 mumol/l) decreased by about 86% the stimulation of the respiration of rat brain synaptosomes induced by veratridine (10 mumol/l). A similar effect was achieved by blocking Na(+)-K(+)-ATPase with ouabain (1 mmol/l). Pharmacological manipulations of Ca homeostasis suggested that the veratridine-induced stimulation of respiration did not depend upon Ca entry. These data suggest that the veratridine-induced stimulation of synaptosomal respiration may result primarily from an increase in intracellular Na+. They provide the basis for an indirect method, which only requires recording of synaptosomal respiration, to test drugs for their possible interaction with excessive Na influxes.
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