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  • Title: Herpes virus type 2 infection and genital symptoms in primary care patients.
    Author: Fleming DT, Leone P, Esposito D, Heitman CK, Justus S, Chin S, Fife KH.
    Journal: Sex Transm Dis; 2006 Jul; 33(7):416-21. PubMed ID: 16601657.
    Abstract:
    OBJECTIVE: We aimed to identify whether genital symptoms were associated with unrecognized herpes simplex virus type 2 (HSV-2) infection in a primary care population. STUDY DESIGN: Five thousand four hundred fifty-two individuals aged 18 to 59 seeking general care at 36 suburban medical offices in 6 U.S. cities were tested for HSV-2 antibody and asked about 10 types of genital symptoms. In patients with no known history of genital herpes, we assessed whether HSV-2 infection was independently associated with symptoms. RESULTS: HSV-2 infection was associated with increases in reports of "sores, blisters, ulcers, crusts, or small cuts/slits" in men [adjusted odds ratio (OR), 1.79; 95% CI, 1.24-2.58] and with increases in reports of "redness, irritation, or a rash" among women (adjusted OR, 1.50; 95% CI, 1.06-2.11). HSV-2 was not significantly associated with other types of genital symptoms. CONCLUSIONS: Primary-care physicians should consider unrecognized HSV-2 infection as a potential cause of some common genital symptoms.
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