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  • Title: Antiproliferative activity of berberine in vitro and in vivo.
    Author: Letasiová S, Jantová S, Múcková M, Theiszová M.
    Journal: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub; 2005 Dec; 149(2):461-3. PubMed ID: 16601810.
    Abstract:
    Berberine, an isoquinoline plant alkaloid acted cytotoxically in vitro on tumour cell lines B16. Its anticancer activity in vivo was studied with the transplanted B16 line in the range of doses from 1 mg/kg to 10 mg/kg. The significant reduction of tumor volume was observed on day 16 at doses of 5 and 10 mg/kg. The dose of 1 mg/kg stimulated the tumor mass, but other tested concentration, 5 and 10 mg/kg, reduced the tumor weight.
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