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  • Title: [Study on molecular genetic structure of Ael blood subgroup].
    Author: Yu Q, Wu GG, Liang YL, Deng ZH, Su YQ, Wang DM.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2006 Apr; 23(2):173-6. PubMed ID: 16604489.
    Abstract:
    OBJECTIVE: To study the ABO allele molecular characteristics of Ael blood subgroup. METHODS: Five individuals of diagnosed as Ael blood subgroup were subjected to PCR amplify ABO alleles using four pairs of sequence-specific primers. Exon 6 and exon 7 at ABO locus of all samples were sequenced. An individual with AelB phenotype was chosen for further analysis of transcript structure of ABO gene. RESULTS: Sequence analysis indicated one Ael phenotype sample with reported Ael01 allele, one Ael phenotype sample with an Ael05 allele, and two AelB and one Ael individuals did not contain referred A allele, but contain O01 or O02 allele with 261G deletion. CONCLUSION: Molecular bases for the Ael have highly polymorphism. The mechanism responsible for the express weak A antigen of O allele with 261G deletion awaits to be elucidated.
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