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  • Title: [Estrogenic effects of gasoline-fueled vehicle exhausts and methanol-fueled vehicle exhausts].
    Author: Wang J, Zhang ZZ, Ye CM, Liang Y, Zhang H.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2006 Mar; 37(2):292-4. PubMed ID: 16608098.
    Abstract:
    OBJECTIVE: To investigate the estrogenic effects of gasoline-fueled vehicle exhausts and methanol-fueled vehicle exhausts and provide a scientific basis for replacement of gasoline by methanol as fuel in vehicle. METHODS: The estrogen-like activities of gasoline-fueled vehicle exhausts and methanol-fueled vehicle exhausts were detected using the recombinant yeast estrogen system. RESULTS: The A600 value of gasoline-fueled vehicle exhausts was 0. 081 when the concentration of gasoline-fueled vehicle exhausts was 1000 mL/mL, and there were significantly statistical differences as compared with those of the dimethyl sulfoxide (DMSO) control group (P < 0.05), which indicated that such concentration had poisonous effects on yeast cell; when the concentration of gasoline-fueled vehicle exhausts was 31.25 mL/mL, the estrogen-like activities of gasoline-fueled vehicle exhausts could be detected, and there were significantly statistical differences as compared with those of the DMSO control group (P<0.05). Besides, the estrogen-like activities could not be detected in other groups with various concentrations. The estrogen-like activities of methanol-fueled vehicle exhausts could not be detected, and there were no significantly statistical differences in A600 value (P > 0.05) when each group was compared with the DMSO control group. CONCLUSION: Gasoline-fueled vehicle exhausts have weak estrogenic effects, whereas methanol-fueled vehicle exhausts have no such effects.
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