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  • Title: Depletion of connexin43-immunoreactivity in astrocytes after kainic acid-induced lesions in rat brain.
    Author: Vukelic JI, Yamamoto T, Hertzberg EL, Nagy JI.
    Journal: Neurosci Lett; 1991 Sep 02; 130(1):120-4. PubMed ID: 1660969.
    Abstract:
    Recent studies have established that the gap junction protein connexin43 is a major structural component of gap junctions between astrocytes in rat brain. Here, we investigated by immunohistochemical methods the effect of kainic acid-induced neuronal degeneration on connexin43 expression by astrocytes. Stereotaxic injections of kainic acid into the thalamus were found to cause a near total depletion of connexin43-immunoreactivity at the lesion site. Areas depleted of connexin43 corresponded to those exhibiting substantial neuronal loss and intense gliosis. These results implicate a neuronal contribution to the regulation of connexin43 expression by astrocytes and, hence, to local control of the potassium spatial buffering capacity afforded by astrocyte gap junctions.
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