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  • Title: Assay of gastrin and somatostatin in gastric antrum tissues of children with chronic gastritis and duodenal ulcer.
    Author: Xie XZ, Zhao ZG, Qi DS, Wang ZM.
    Journal: World J Gastroenterol; 2006 Apr 14; 12(14):2288-90. PubMed ID: 16610039.
    Abstract:
    AIM: To study the expressions of gastrin (GAS) and somatostatin (SS) in gastric antrum tissues of children with chronic gastritis and duodenal ulcer and their role in pathogenic mechanism. METHODS: Specimens of gastric antrum mucosa from 83 children were retrospectively analyzed. Expressions of GAS and SS in gastric antrum tissues were assayed by the immunohistochemical En Vision method. RESULTS: The expressions of GAS in chronic gastritis Hp+ group (group A), chronic gastritis Hp-group (group B), the duodenal ulcer Hp+group (group C), duodenal ulcer Hp-group (group D), and normal control group (group E) were 28.50+4.55, 19.60+2.49, 22.69+2.71, 25.33+4.76, and 18.80+2.36, respectively. The value in groups A-D was higher than that in group E. The difference was not statistically significant. The expressions of SS in groups A-E were 15.47+1.44, 17.29+2.04, 15.30+1.38, 13.11+0.93 and 12.14+1.68, respectively. The value in groups A-D was higher than that in group E. The difference was also not statistically significant. CONCLUSION: The expressions of GAS and SS are increased in children with chronic gastritis and duodenal ulcer.
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