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  • Title: Prospective serial study of viral change in the cervix and correlation with human papillomavirus genome status.
    Author: Kitchener HC, Neilson L, Burnett RA, Young L, Macnab JC.
    Journal: Br J Obstet Gynaecol; 1991 Oct; 98(10):1042-8. PubMed ID: 1661138.
    Abstract:
    OBJECTIVE: To observe in serial fashion the histological changes of human papilloma virus (HPV) infection of the cervix and to correlate these with the detection of HPV genomes. DESIGN: A prospective longitudinal study to perform colposcopy and at 0, 9 and 18 months to obtain a smear, a biopsy for histology and HPV-16 genome detection by DNA/DNA hybridization. SETTING: Glasgow Family Planning Centre. SUBJECTS: Eighty-two women recruited on the basis of a routine smear showing viral change without dyskaryosis. INTERVENTIONS: Women found to have CIN 3 were treated with laser. MAIN OUTCOME MEASURES: Cytology and cervical biopsy results and HPV-16 DNA detection by Southern blotting obtained serially from individual subjects. RESULTS: Of 82 women recruited, 10% were positive for HPV-16 detection by Southern blotting. Detection of HPV-16 genomes did not correlate with either CIN or viral infection assessed histologically and serial hybridizations in a given individual showed fluctuation in HPV-16 detection. Polymerase chain reaction in a subset of samples revealed 46% positive for HPV DNA. CONCLUSION: No clear correlation exists between HPV genome detection and the histological appearance. HPV-16 genome detection alone may not be a useful predictor of precancerous progression.
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