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  • Title: [Effect of new qingkailing injection on cerebral edema following intracerebral hemorrhage in rats].
    Author: Liu M, Guo MZ, Li PY, Zhang H, Li L, Li P, Wang Q.
    Journal: Zhongguo Zhong Xi Yi Jie He Za Zhi; 2006 Mar; 26(3):244-7. PubMed ID: 16613272.
    Abstract:
    OBJECTIVE: To investigate the effect of New Qingkailing injection (NQKLI) on cerebral edema following intracerebral hemorrhage (ICH) induced by collagenase VII in rats. METHODS: After being established into ICH model by collagenase VII, rats were treated with NQKLI by intraperitoneal injection. Forty-eight hrs later, brain contents of water was detected with wet and dry method, calcium content in brain was detected by atomic spectrophotometer, tumor necrosis factor-alpha (TNF-alpha) in brain tissue was determined by liquid competitive ibhibitory immunoassay, and serum matrix metalloproteinase-9 (MMP-9) were detected with enzyme-linked immunosorbent assay (ELISA) respectively. RESULTS: NQKLI reduced the contents of water, calcium and TNF-alpha content of brain tissue and serum MMP-9 in rats with ICH. CONCLUSION: NQKLI could alleviate both vasogenic and cytotoxic cerebral edema by prohibiting calcium over-load, protecting basilar membrane and eliminating inflammation.
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