These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Role of efaproxiral in metastatic brain tumors.
    Author: Engel RH, Kaklamani VG.
    Journal: Expert Rev Anticancer Ther; 2006 Apr; 6(4):477-85. PubMed ID: 16613536.
    Abstract:
    Brain metastases from breast cancer are common and cause significant morbidity and mortality. Treatment with whole-brain radiotherapy provides a median survival of only 4-6 months. One mechanism affecting sensitivity to radiation is tumor oxygenation. Hypoxic tumor cells are more likely to be resistant to radiation and adversely affect prognosis. For nearly 70 years, all attempted modalities have failed to circumvent tumor hypoxia and increase tumor death. Abraham and colleagues developed a fibric acid derivative that would cause the displacement of oxygen from hemoglobin and improve tissue oxygenation. After modifications to enhance absorption into the red blood cell, RSR13 (efaproxiral) was developed. Efaproxiral was found to be safe and improved tumor oxygenation in preclinical studies. Early Phase I and II trials supported the earlier preclinical evidence while demonstrating that efaproxiral was safe and effective. A randomized Phase III study, Radiation Enhancing Allosteric Compounds of Hypoxic brain metastases (REACH, RT-009), failed to show a significant improvement in overall survival in all eligible patients treated with efaproxiral and whole-brain radiation. However, there was a statistically significant improvement in median survival and quality of life within a subset of metastatic breast cancer patients. Efaproxiral is currently being studied with radiotherapy in a confirmatory trial in the treatment of brain metastases from breast cancer. Furthermore, the combination of efaproxiral with radiotherapy is being investigated in other solid tumors.
    [Abstract] [Full Text] [Related] [New Search]