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  • Title: Intracerebral hematoma as a complication of intrathecal methotrexate administration.
    Author: Boran P, Tokuc G, Boran BO, Oktem S.
    Journal: Pediatr Blood Cancer; 2008 Jan; 50(1):152-4. PubMed ID: 16615061.
    Abstract:
    Neurotoxicity of methotrexate is a well-documented issue, but development of an intracerebral hematoma following administration of intrathecal methotrexate is an extremely rare entity. A 6-year-old male with the diagnosis of non-Hodgkin lymphoma was put on a treatment regimen, including intrathecal methotrexate. Six days following the last intrathecal methotrexate administration, the patient developed a deteriorating state of consciousness. There was no history of trauma. Coagulation studies and platelet count were normal. Magnetic resonance imaging of the brain demonstrated a large left frontoparietal hematoma. Intracerebral hematoma may be a very rare, but serious, complication of intrathecal methotrexate administration.
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