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  • Title: Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors.
    Author: Vandromme L, Piguel S, Lozach O, Meijer L, Legraverend M, Grierson DS.
    Journal: Bioorg Med Chem Lett; 2006 Jun 15; 16(12):3144-6. PubMed ID: 16616489.
    Abstract:
    A new series of 2-aryl-substituted purine derivatives has been synthesized by Suzuki Pd(0) coupling reactions. Moderate in vitro inhibitory activity against Cdk1 and Cdk5 was observed. These compounds are inactive against GSK3.
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