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  • Title: Chemoenzymatic synthesis of both enantiomers of alpha-tocotrienol.
    Author: Chênevert R, Courchesne G, Pelchat N.
    Journal: Bioorg Med Chem; 2006 Aug 01; 14(15):5389-96. PubMed ID: 16616508.
    Abstract:
    The stereoselective acylation of the achiral chromanedimethanol derivative 1 by vinyl acetate in the presence of Candida antarctica lipase B gave the (S)-monoester 2 in high enantiomeric purity (ee > or = 98%). Enzymatic hydrolysis of diesters of compound 1 failed to give (R)-monoester 2 in good yield and high ee. Thus, both enantiomers of alpha-tocotrienol were synthesized from the (S)-monoester 2.
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