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  • Title: Gastrin releasing peptide, but not pentagastrin, stimulates ACTH and cortisol secretion in conscious dogs.
    Author: Sander LD, Thomas RM.
    Journal: Regul Pept; 1991 Aug 13; 35(2):127-33. PubMed ID: 1661903.
    Abstract:
    Gastrin releasing peptide (GRP) is the mammalian equivalent of bombesin. Bombesin has been shown to stimulate canine ACTH and cortisol secretion in a dose-related manner. In the present study, following a 30-40 min saline infusion, a progressively-increasing, stepwise infusion of GRP (60, 600, 1200 pmol/kg per h) or pentagastrin (PG) (2, 4, 8 micrograms/kg per h) was administered. Each drug dose was infused for 40-45 min and blood samples were drawn at 20-22.5 min intervals. GRP caused significant, dose-dependent increases in plasma ACTH (145 +/- 6%, 242 +/- 49%, 270 +/- 78% of control) and cortisol (158 +/- 16%, 218 +/- 26%, 250 +/- 62% of control). The dose of GRP required for a half-maximal cortisol response was 120 pmol/kg per h, while that for ACTH was 140 pmol/kg per h. PG had no effect on either ACTH or cortisol. While PG is apparently not involved in GRP/bombesin release of ACTH or cortisol, similar mechanisms of action for GRP and bombesin are suggested by their equimolar potencies.
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