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  • Title: Anticonvulsant evaluation and mechanism of action of benzylamino enaminones.
    Author: Edafiogho IO, Ananthalakshmi KV, Kombian SB.
    Journal: Bioorg Med Chem; 2006 Aug 01; 14(15):5266-72. PubMed ID: 16621576.
    Abstract:
    The mechanism of anticonvulsant action was evaluated for the benzylamino enaminones. The most potent enaminone in this series was the unsubstituted benzylamine analog (30; methyl 4-benzylamino-6-methyl-2-oxocyclohex-3-en-1-oate) which had an oral effective dose (ED50) in rats of 27 mg/kg against maximal electroshock seizures, and a concentration 10-fold less than this dose depressed excitatory synaptic transmission, and action potential firing in the rat brain in vitro.
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