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  • Title: Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases.
    Author: Pantaleo G, Harari A.
    Journal: Nat Rev Immunol; 2006 May; 6(5):417-23. PubMed ID: 16622477.
    Abstract:
    At present, we only have indirect knowledge of the protective role of antigen-specific T cells in human viral infections, and it has been difficult to show a direct correlation between quantitative and qualitative measures of T-cell immunity and virus-associated diseases. However, as described in this Opinion article, recent advances in the characterization of T-cell functions and in the development of standardized T-cell assays have led to the identification of distinct functional signatures of T-cell responses that correlate with levels of viral replication and disease activity.
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