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  • Title: [Olfactory groove meningioma: correlation between clinicoradiological features and proliferative index (Mib-1)].
    Author: Paiva Neto MA, Tella OI, Herculano MA, Stávale JN, Bonatteli AP.
    Journal: Arq Neuropsiquiatr; 2006 Mar; 64(1):77-82. PubMed ID: 16622558.
    Abstract:
    OBJECTIVE: The aim of this study is to correlationate demographic, radiologic features and proliferative index defined by immunohistochemical expression of Mib-1 in olfactory groove meningiomas, and to observe possible predictive factors of recurrence of this tumor. METHOD: There were analysed demographic, clinical and radiological features of 15 patients with olfactory groove meningioma. Fifteen paraffin-embebed tumors were studied by immunohistochemical methods for the expression of proliferative index by the Mib-1. RESULTS: There was a statistically positive correlation between tumoral and edema volumes. There was no correlation between Mib-1, tumoral volume, tumoral edema and frontal skull base abnormalities. Two cases with tumor recurrence had proliferative indices higher than the mean index. CONCLUSION: Larger tumors were more susceptible to develop peritumoral edema. The proliferative índex has no positive correlation with tumoral volume, edema volumes and skull base invasion, but probably it is associated with tumoral recurrence.
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