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  • Title: Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents.
    Author: Ottesen LK, Ek F, Olsson R.
    Journal: Org Lett; 2006 Apr 27; 8(9):1771-3. PubMed ID: 16623547.
    Abstract:
    [reaction: see text] A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO(2)Me) gave excellent yields (89%).
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