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  • Title: Resin-bound dynamic combinatorial chemistry.
    Author: McNaughton BR, Miller BL.
    Journal: Org Lett; 2006 Apr 27; 8(9):1803-6. PubMed ID: 16623555.
    Abstract:
    [reaction: see text] Dynamic combinatorial chemistry (DCC) is a promising technique for receptor-aided selection of high-affinity ligands from equilibrating combinatorial libraries. Identification of the specific ligand(s) selected is often challenging, however, due to difficulties associated with chromatographic separation and/or mass degeneracy within the library. Herein, we describe proof-of-concept experiments demonstrating a new technique termed resin-bound DCC (RB-DCC), which provides a solution to this problem.
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