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  • Title: Caffeine prolongs exercise duration in heart failure.
    Author: Notarius CF, Morris B, Floras JS.
    Journal: J Card Fail; 2006 Apr; 12(3):220-6. PubMed ID: 16624688.
    Abstract:
    BACKGROUND: Caffeine increases submaximal exercise performance in healthy young subjects; its effects on exercise tolerance in heart failure (HF) have not been characterized. METHODS AND RESULTS: To determine whether caffeine increases exercise tolerance in HF, caffeine (4 mg/kg intravenously, equivalent to 2 cups of coffee) or vehicle were infused into 10 treated HF patients (left ventricular ejection fraction 25 +/- 2 %), and 10 age-matched normal subjects (N) on 2 separate days in a double-blind, randomized, crossover design. We measured heart rate, blood pressure, and ventilation at rest and during graded cycling (15 W/minute) to peak effort. Peak oxygen consumption was unaffected in either group. Mean exercise time was unchanged in N (1,013 +/- 87 versus 988 +/- 107 seconds; P = .86) but was significantly increased by caffeine in HF (from 511 +/- 28 to 560 +/- 37 seconds; P = .004) despite an increase in peak minute ventilation (P < .05). Resting and peak blood pressures were higher after caffeine (P < .05) in HF, not N. CONCLUSION: Caffeine allows HF patients to exercise longer at peak effort.
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