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  • Title: [Analysis of auditory steady-state response to multiple simultaneous stimuli and cochlea morphology in guinea pigs with posterior semicircular canal fistula].
    Author: Xie NP, Chen GQ, Yang X, Shu SY.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2006 Apr; 26(4):495-7. PubMed ID: 16624763.
    Abstract:
    OBJECTIVE: To observe the changes of auditory steady-state response (ASSR) threshold in guinea pigs with posterior semicircular canal fistula. METHODS: In 10 guinea pigs, a window was opened in the posterior semicircular canal of the left ear with the right ear serving as the control for testing the ASSR under anesthesia with pentobarbital sodium. RESULTS: The mean and standard deviation of ASSR threshold (dB SPL) at 0.5, 1, 2, and 4 kHz in the left ear was 35.00+/-14.33, 25.50+/-12.37, 20.00+/-9.37 and 20.00+/-9.18, respectively, and was 31.00+/-16.19, 25.50+/-12.34, 18.00+/-6.96 and 18.50+/-6.71 in the right ear, respectively. Paired-sample t test showed no significant difference in the ASSR at the same frequency between the two ears. CONCLUSION: Small fistula by surgery causes no significant hearing loss in guinea pigs.
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