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  • Title: [Effect of Shenkangwan on mesangial cell NO and TGF-beta1 excretion in rats with early diabetic nephropathy].
    Author: Chen GB, Wei LB, Xiao W, Long HB.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2006 Apr; 26(4):526-8. PubMed ID: 16624774.
    Abstract:
    OBJECTIVE: To study the mechanism of Shenkangwan (SKW) in treating early diabetic nephropathy (DN). METHODS: The effect of SKW on NO and transforming growth factor (TGF)-beta(1) production by the mesangial cells (MCs) of rats with early diabetic nephropathy was evaluated with serum pharmacological method. RESULTS: Compared with normal serum, the SKW-containing serum dose- and time-dependently inhibited TGF-beta(1) excretion and increased NO production in the MCs of rats with early DN (P<0.05 and P<0.01, respectively). CONCLUSION: The therapeutic effect of SKW on early DN may rely on the balance modulation of cytokine network by increasing NO production and decreasing TGF-beta(1) excretion to prevent cytokine-induced damage of the MCs.
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