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  • Title: [Progressive nodular histiocytosis--rare variant of cutaneous non-Langerhans cell histiocytosis].
    Author: Lüftl M, Seybold H, Simon M, Burgdorf W.
    Journal: J Dtsch Dermatol Ges; 2006 Mar; 4(3):236-8. PubMed ID: 16626320.
    Abstract:
    Progressive nodular histiocytosis is an extremely rare skin disease is clinically characterized by the coincidence of two distinct lesions, namely, superficial xanthomatous papules up to 5 mm and deep nodules and tumors 1-3 cm. Histologically the nodules represent spindle cell xanthogranulomas. We report a 24-year-old women with these findings. The distinction from other non-Langerhans cell histiocytoses, in particular multiple juvenile xanthogranulomas, which may be more likely to show spontaneous remission, is somewhat unclear; patients with progressive nodular histiocytosis usually follow a serious and disfiguring clinical course.
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