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  • Title: Sulfasalazine prevents apoptosis in spermatogenic cells after experimental testicular torsion/detorsion.
    Author: Zhao YG, Zheng XM, Zhou J, Liu XL, Hu XM, Chen DH, Zhang XJ, Men XW, Shi HB, Yu ZY.
    Journal: Acta Pharmacol Sin; 2006 May; 27(5):603-8. PubMed ID: 16626516.
    Abstract:
    AIM: To determine whether sulfasalazine can prevent apoptosis in spermatogenic cells by preventing the activation of NF-kappaB in spermatogenic epithelium in experimental testicular torsion. METHODS: Thirty-two adult male Sprague-Dawley rats were subjected to unilateral 720 degree testicular torsion for durations of 0 h and 2 h, then the torsion was relieved. The ischemic/reperfused testes were collected for the detection of NF-kappaB expression with Western blotting and immunohistochemistry techniques, and detection of apoptosis with TUNEL techniques. RESULTS: The NF-kappaB coefficient of spermatogenic epithelium and the apoptosis index of spermatogenic cells were significantly different in the operation and the sham-operation groups after experimental testicular torsion (P<0.01). CONCLUSION: NF-kappaB activation of spermatogenic epithelium is related to apoptosis of spermatogenic cells. Sulfasalazine can prevent apoptosis in spermatogenic cells after the experimental testicular torsion through prevention of NF-kappaB activation.
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