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  • Title: Molecular diagnosis of culture-negative cerebral nocardiosis due to Nocardia abscessus.
    Author: Marchandin H, Eden A, Jean-Pierre H, Reynes J, Jumas-Bilak E, Boiron P, Laurent F.
    Journal: Diagn Microbiol Infect Dis; 2006 Jul; 55(3):237-40. PubMed ID: 16626912.
    Abstract:
    We describe a case of culture-negative cerebral nocardiosis in a 34-year-old immunocompetent man who presented multiple cerebral abscesses. All bacteriologic cultures were negative. Nocardiosis was diagnosed by using a direct genus-specific 16S rDNA amplification method, and Nocardia abscessus was identified by hsp65 sequence analysis. The patient is alive and well on imipenem and doxycycline therapy, 14 months after onset.
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