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  • Title: Epstein-Barr virus reactivation in a patient treated with anti-thymocyte globulin for severe aplastic anemia.
    Author: Calistri E, Tiribelli M, Battista M, Michelutti A, Corbellino M, Viale P, Fanin R, Damiani D.
    Journal: Am J Hematol; 2006 May; 81(5):355-7. PubMed ID: 16628717.
    Abstract:
    Epstein-Barr virus (EBV) infection and reactivation is an increasing complication in immune deficient patients, particularly after allogeneic hematopoietic stem cell transplantation (HSCT). Therapy with anti-thymocyte globulin (ATG) is associated with higher incidence of EBV-related disease in HSCT patients, but this risk is not documented in patients receiving ATG for severe aplastic anemia (SAA). We describe the case of a patient who developed an EBV infection, with the clinical features of an infectious mononucleosis, after immune suppression with cyclosporine and two courses of ATG for SAA.
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