These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: DNA-binding by functionalized gold nanoparticles: mechanism and structural requirements.
    Author: Goodman CM, Chari NS, Han G, Hong R, Ghosh P, Rotello VM.
    Journal: Chem Biol Drug Des; 2006 Apr; 67(4):297-304. PubMed ID: 16629827.
    Abstract:
    A family of nanoparticles featuring surfaces of varying hydrophobicity was synthesized. The efficiency of DNA-binding was determined, demonstrating in a fivefold modulation in binding a 37-mer DNA strand. Nanoparticle-binding causes a reversible conformational change in the DNA structure, as demonstrated by circular dichroism and fluorescence experiments. Furthermore, the affinity of the nanoparticle for the DNA can be regulated by external agents, though stability of the complex is observed at relatively high ionic strengths.
    [Abstract] [Full Text] [Related] [New Search]