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  • Title: Synthesis and pharmacology of a novel class of long-lasting PAF receptor antagonists.
    Author: Houlihan WJ, Cheon SH, Handley DA, Larson DA.
    Journal: J Lipid Mediat; 1991; 3(1):91-9. PubMed ID: 1662991.
    Abstract:
    Several new charged PAF receptor antagonists were prepared, where the phosphate moiety has been replaced by a methylsulfonylcarbamoylpyridinium moiety, and evaluated for duration of inhibitory activity against PAF-induced bronchoconstriction and hemoconcentration in the guinea pig. One of these compounds (1d; SDZ 64-619) has shown potency and duration of inhibition in the range of CV-6209 (1c).
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