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  • Title: Nck links nephrin to actin in kidney podocytes.
    Author: Tryggvason K, Pikkarainen T, Patrakka J.
    Journal: Cell; 2006 Apr 21; 125(2):221-4. PubMed ID: 16630808.
    Abstract:
    Two papers, one in Nature (Jones et al., 2006) and the other in the Journal of Clinical Investigation (Verma et al., 2006) show that Nck adaptor proteins connect phosphorylated nephrin with actin polymerization in podocyte foot processes, structures important for slit-diaphragm formation in the kidney. Their results further our understanding of podocyte development and repair in glomerular disease.
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