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  • Title: The chronically reserpinized rat as a possible model for cystic fibrosis. I. Submaxillary gland morphology and ultrastructure.
    Author: Martinez JR, Adelstein E, Quissel D, Barbero GJ.
    Journal: Pediatr Res; 1975 May; 9(5):463-9. PubMed ID: 166347.
    Abstract:
    Rats treated for 7 days with reserpine develop structural changes in the submaxillary gland that resemble those that have been reported in cystic fibrosis. The salivary exocrinopathy is characterized by increased amounts of PAS-reactive mucoprotein in the acinar cells and by obstruction and dilatation of ducts by precipitated material with the same staining characteristics as those found in the acinar elements.
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