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  • Title: Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.
    Author: Copani A, Raciti G, Bruno V, Sortino MA, Nicoletti F, Canonico PL, Cambria A.
    Journal: Ital J Biochem; 1991; 40(5):289-94. PubMed ID: 1663495.
    Abstract:
    Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.
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