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  • Title: Therapeutic effect of llama derived VHH fragments against Streptococcus mutans on the development of dental caries.
    Author: Krüger C, Hultberg A, Marcotte H, Hermans P, Bezemer S, Frenken LG, Hammarström L.
    Journal: Appl Microbiol Biotechnol; 2006 Oct; 72(4):732-7. PubMed ID: 16636830.
    Abstract:
    Streptococcus mutans is the main cause of dental caries. We evaluated the therapeutic effect of variable regions of a llama heavy chain antibody fragments directed against S. mutans named S36-VHH (S for Streptococcus) alone or fused with glucose oxidase (GOx) from Aspergillus niger. Western blot analysis and ELISA revealed binding of the S36-VHH to the streptococcal antigen I/II adhesin molecule of S. mutans serotype C. In a rat-desalivated caries model, daily administration of S36-VHH significantly reduced the development of smooth surface caries. No additional therapeutic effect of GOx was observed. Our results suggest that llama VHH antibodies may be a potential benefit as prophylaxis against dental caries.
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