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  • Title: [The functional state of the adrenal cortex in patients with gonadal dysgenesis and a female phenotype].
    Author: Genkova P, Kolarov P, Dokumov S, Spasov S, Stancheva M.
    Journal: Probl Endokrinol (Mosk); 1975; 21(1):43-6. PubMed ID: 166369.
    Abstract:
    Excretion of 17-KS and 17-OCS was studied in the urine of 86 patients with various cytogenetic variants of gonad dysgenesis of a female phenotype under basic conditions and after ACTH stimulation; in 10 patients endogenous hypophyseal ACTH reserve after block of the adrenal cortex by metopyrone was investigated as well. A conclusion was drawn on the presence in these patients of differnet types of deviations of the adrenal gland function. In some of the cases there is a primary "global" or dissociated injury of the adrenal cortex, apparently directly associated with gonosome anomaly; in other cases--with disturbed regulation of ACTH secretion.
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