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  • Title: [The effect of STH, TTH and ACTH on several aspects of copper, sodium and potassium metabolism in the livers of hypophysectomized white rats].
    Author: Kovtuniak NA, Meshchishen IF, Iarmol'chuk GM.
    Journal: Probl Endokrinol (Mosk); 1975; 21(1):79-83. PubMed ID: 166374.
    Abstract:
    It was found in experiments on male albino rats that hypophysectomy was accompanied by an increase of potassium (on account of its accumulation in the mitochondria, nuclei and the microsomes) and copper in the liver. At the same time there was an increase in this organ of tha activity of Mg-2+-Na-+-K-+-ATPase and Mg-+-ATPase, and also a rise of ceruloplasmin activity in the blood serum. STH and TTH restored the sodium content to the normal and increased potassium level in the liver of hypophysectomized rats. ACTH and STH increased copper content in the hepatic tissue and normalized the activity of ceruloplasmin in the blood. All the hormones used promoted normalization of ATP-ase activity.
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