These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Palmerolide A, a cytotoxic macrolide from the antarctic tunicate Synoicum adareanum.
    Author: Diyabalanage T, Amsler CD, McClintock JB, Baker BJ.
    Journal: J Am Chem Soc; 2006 May 03; 128(17):5630-1. PubMed ID: 16637618.
    Abstract:
    Palmerolide A, a 20-membered macrocyclic polyketide bearing carbamate and vinyl amide functionality, was isolated from the tunicate Synoicum adareanum collected from the vicinity of Palmer Station on the Antarctic Peninsula. Palmerolide A displays potent and selective cytotoxicity toward melanoma (UACC-66 LC50 = 0.018 muM) and appears to operate via inhibition (IC50 = 2 nM) of V-ATPase.
    [Abstract] [Full Text] [Related] [New Search]