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  • Title: Invasive squamous cell carcinoma arising in refractory perianal Bowen's disease in a HIV-positive individual.
    Author: Herat A, Shirato K, Damian DL, Finlayson R, Whitfeld M.
    Journal: Australas J Dermatol; 2006 May; 47(2):120-3. PubMed ID: 16637809.
    Abstract:
    A 54-year-old HIV-positive homosexual man presented with erythematous and pigmented plaques on background erythema in the perianal region, histologically consistent with Bowen's disease. Perianal Bowen's disease represents high-grade anal intraepithelial neoplasia, which is considered a precursor lesion of invasive anal squamous cell carcinoma. This patient's anal intraepithelial neoplasia was unresponsive to multiple treatment modalities including cryotherapy, serial curettage and cautery, topical 5-fluorouracil and 5-aminolaevulinic acid photodynamic therapy. He progressed to develop a poorly differentiated squamous cell carcinoma of the anus three and a half years after the Bowen's disease was diagnosed. The squamous cell carcinoma was treated with combined chemoradiation. A recurrence of high-grade anal intraepithelial neoplasia was noted 6 months after completion of chemoradiation.
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