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  • Title: Neuropsychological test profiles in schizophrenia and non-psychotic depression.
    Author: Rund BR, Sundet K, Asbjørnsen A, Egeland J, Landrø NI, Lund A, Roness A, Stordal KI, Hugdahl K.
    Journal: Acta Psychiatr Scand; 2006 Apr; 113(4):350-9. PubMed ID: 16638080.
    Abstract:
    OBJECTIVE: The study examined to what degree schizophrenia is characterized by a neuropsychological (NP) test profile specific in shape and level compared with depression and normal functioning. METHOD: Fifty-three patients with schizophrenia, 45 with non-psychotic depression, and 50 normals were assessed with a comprehensive NP test battery and clinical instruments. NP test scores were factor analyzed into seven composite scores. RESULTS: Schizophrenia patients performed significantly below normals across all seven composite scores, whereas depression patients were impaired in two. Verbal memory was most impaired. Sixty-two percent of schizophrenia patients were moderately or severely impaired, the corresponding figure for depression was 28%. Impairment was moderately associated with IQ level and clinical symptom load in schizophrenia, but not in depression. CONCLUSION: Schizophrenia is characterized by deficits across a wide range of NP functions. Thirty-eight percent of the patients are within normal limits. A mild and limited NP disturbance is apparent in depression.
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