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  • Title: Anti-staphylococcal activity of temafloxacin, ciprofloxacin, ofloxacin and enoxacin.
    Author: Barry AL, Fuchs PC.
    Journal: J Antimicrob Chemother; 1991 Nov; 28(5):695-9. PubMed ID: 1663929.
    Abstract:
    Four fluoroquinolones were tested for antimicrobial activity against 300 isolates of staphylococci collected from medical centres throughout the United States. No cross-resistance to methicillin or oxacillin and the fluoroquinolones was observed. All four drugs were bactericidal agents and all ciprofloxacin-susceptible strains were inhibited at recommended breakpoint concentrations. Ciprofloxacin-resistant strains showed complete cross-resistance to the other fluoroquinolones. The relative potency of the study drugs as judged by MIC/MBC determinations was: temafloxacin greater than ciprofloxacin greater than ofloxacin greater than enoxacin.
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