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  • Title: Nebulized amphotericin B combined with intravenous amphotericin B in rats with severe invasive pulmonary aspergillosis.
    Author: Ruijgrok EJ, Fens MH, Bakker-Woudenberg IA, van Etten EW, Vulto AG.
    Journal: Antimicrob Agents Chemother; 2006 May; 50(5):1852-4. PubMed ID: 16641459.
    Abstract:
    Nebulized amphotericin B (AMB) combined with intravenous AMB was studied in persistently leukopenic rats with invasive pulmonary aspergillosis. Pulmonary concentrations of AMB after aerosol treatment were substantially higher than after intravenous liposomal AMB. Nebulized liposomal AMB in addition to intravenous AMB resulted in significantly prolonged survival compared to controls.
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