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  • Title: Significance of mutations in embB codon 306 for prediction of ethambutol resistance in clinical Mycobacterium tuberculosis isolates.
    Author: Plinke C, Rüsch-Gerdes S, Niemann S.
    Journal: Antimicrob Agents Chemother; 2006 May; 50(5):1900-2. PubMed ID: 16641474.
    Abstract:
    We analyzed 159 Mycobacterium tuberculosis isolates (101 ethambutol [EMB]-resistant strains, 33 multidrug-resistant but not EMB-resistant strains, and 25 fully susceptible strains) for the presence of mutations in embB codon 306 (embB306). Mutations were detected only in EMB-resistant strains (n = 69; 68%), thus confirming the significance of embB306 mutations for the prediction of resistance to EMB.
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