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  • Title: [Etiology of aseptic meningitis prevalent in Xuzhou].
    Author: Li X, Guo XL, Shi ZY, Ni DX, Wang H.
    Journal: Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi; 2006 Mar; 20(1):66-9. PubMed ID: 16642223.
    Abstract:
    BACKGROUND: To find the pathogenic agents of aseptic meningitis prevalent in Xuzhou of Jiangsu province in 2001. METHODS: The enterovirus (EV) was cultured from CSF of the patients and identified with anti-serum by neutralization test. Neutralization titer of antibody in paired sera from meningitis children was determined. EV RNA was detected by RT-PCR. RESULTS: Four strains of Coxsackievirus B5, 2 strains of Coxsackievirus B3 and 1 strain of Echovirus 7 were isolated from 22 CSF specimens. The isolation rate of virus was 31.8% (7/22), 21 CSF were tested by RT-PCR, the positive rate of EV RNA was 52.4% (11/21); 57.9% (11/19) of patients paired-sera had over 4 folds antibody rise or became seroconverted. CONCLUSION: Enterovirus was the pathogenic agent of aseptic meningitis prevalent in Xuzhou of Jiangsu province, the main serotype of the virus was Coxsackievirus B5.
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