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  • Title: Discovering new natural products directly from crude extracts by HPLC-SPE-NMR: chinane diterpenes in Harpagophytum procumbens.
    Author: Clarkson C, Staerk D, Hansen SH, Smith PJ, Jaroszewski JW.
    Journal: J Nat Prod; 2006 Apr; 69(4):527-30. PubMed ID: 16643019.
    Abstract:
    HPLC-SPE-NMR experiments with crude extracts of Harpagophytum procumbens allowed the rapid identification of novel, unstable chinane-type tricyclic diterpenes (1 and 2), along with numerous other constituents. Dramatic sensitivity gains achieved with this novel hyphenated technique establish a new paradigm in natural products research: rapid and rigorous structure determination of multiple extract components, including minor components, without preparative-scale isolation.
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