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  • Title: [The central gray substance of the midbrain: the role of corticosteroids in the analgesic effect].
    Author: Iarushkina NI, Bogdanov AI, Filaretov AA.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1991 Apr; 77(4):83-9. PubMed ID: 1664365.
    Abstract:
    The effect of stimulation of periaqueductal gray matter on pain threshold and blood corticosteroids was studied in anesthetized rats. The stimulation with 30-50-microA current resulted in an increase of analgesia and blood corticosteroids. An increase of current intensity up to 100 microA resulted in a decreasing corticosteroid level and analgetic effect. The magnitude and duration of the analgesia were decreased after blocking the pituitary-adrenocortical system. The corticosteroids seem to induce analgesia after stimulation of periaqueductal gray matter stimulation.
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