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  • Title: [Effects of inosine injection in expression of myosin heavy chain in intrafusal and extrafusal myofibers in soleus muscle of tail-suspended rats].
    Author: Shi L, Fan XL, Wu SD.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2006 May; 22(3):318-20. PubMed ID: 16643789.
    Abstract:
    AIM: To study the effects of inosine on myosin heavy chain (MHC) activity in rats soleus muscle after tail-suspension. METHODS: Weightlessness was simulated by tail-suspension of rats. Using immunohistochemistry technique, changes of expression of MHC in intrafusal and extrafusal fibers in soleus muscle were detected. RESULTS: Expression of fast MHC in intrafusal and extrafusal fibers in soleus muscle increased after 14 d of simulated weightlessness, whereas in tail-suspended rats given inosine, the expression of fast MHC was not detected. CONCLUSION: Inosine could counteract the changes in expression of MHC in intrafusal and extrafusal fibers of rats soleus under simulated weightless situation.
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